Pharmacology of GPCRs Biased Signaling and Agonists
Pharmacology of GPCRs Biased Signaling and Agonists | 11.94 MB
Title: Pharmacology of GPCRs Biased Signaling and Agonists
Author: Zijian Li, Kunhong Xiao
Category: Nonfiction, Health & Well Being, Medical, Medical Science, Pharmacology, Science & Nature, Science, Biological Sciences, Genetics, Specialties, Psychiatry
Language: English | 347 Pages | ISBN: 9783032132291
Description:
The book Pharmacology of GPCRs Biased Signaling and Agonists explores the intricate world of G protein-coupled receptors (GPCRs), a diverse and crucial family of cell surface receptors that play a pivotal role in mediating the effects of various signaling molecules. The book places its focus on understanding biased signaling, a phenomenon where GPCRs can activate multiple signaling pathways upon binding to different ligands. Unlike traditional views that considered GPCRs as simple "on-off" switches, biased signaling reveals the complexity of these receptors, allowing for selective activation of specific cellular responses. This concept has profound implications for pathological mechanism and drug development. Coverage in the topics, including the molecular mechanisms underlying biased signaling, the structural basis of GPCR biased signaling and ligands, the identification and characterization of biased agonists, drug discovery and development of biased agonists and the therapeutic potential of targeting specific signaling pathways for various diseases.The exploration of GPCR biased signaling and agonists is vital for advancing our understanding of cell signaling processes and refining drug development strategies.
DOWNLOAD:
https://rapidgator.net/file/b975087e861bbb9a8b99dc91182de4bd/Pharmacology_of_GPCRs_Biased_Signaling_and_Agonists.pdf
https://nitroflare.com/view/99D0FAA653BFBEC/Pharmacology_of_GPCRs_Biased_Signaling_and_Agonists.pdf
The book Pharmacology of GPCRs Biased Signaling and Agonists explores the intricate world of G protein-coupled receptors (GPCRs), a diverse and crucial family of cell surface receptors that play a pivotal role in mediating the effects of various signaling molecules. The book places its focus on understanding biased signaling, a phenomenon where GPCRs can activate multiple signaling pathways upon binding to different ligands. Unlike traditional views that considered GPCRs as simple "on-off" switches, biased signaling reveals the complexity of these receptors, allowing for selective activation of specific cellular responses. This concept has profound implications for pathological mechanism and drug development. Coverage in the topics, including the molecular mechanisms underlying biased signaling, the structural basis of GPCR biased signaling and ligands, the identification and characterization of biased agonists, drug discovery and development of biased agonists and the therapeutic potential of targeting specific signaling pathways for various diseases.The exploration of GPCR biased signaling and agonists is vital for advancing our understanding of cell signaling processes and refining drug development strategies.
DOWNLOAD:
https://rapidgator.net/file/b975087e861bbb9a8b99dc91182de4bd/Pharmacology_of_GPCRs_Biased_Signaling_and_Agonists.pdf
https://nitroflare.com/view/99D0FAA653BFBEC/Pharmacology_of_GPCRs_Biased_Signaling_and_Agonists.pdf
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