Follows the lives of the personnel of the fictional 21st District, which houses both uniformed officers and the department's elite Intelligence Unit as they fight every day to keep the city of Chicago, Illinois safe.

Follows the lives of the personnel of the fictional 21st District, which houses both uniformed officers and the department's elite Intelligence Unit as they fight every day to keep the city of Chicago, Illinois safe.

Follows both the professional and personal lives of the firefighters, rescue personnel, and paramedics of the Chicago Fire Department at the fictional Firehouse 51 as they risk their lives to save and protect the city of Chicago, ...

The city's most highly skilled medical team saves lives, while navigating their unique interpersonal relationships.